Kisspeptin
A brain peptide that sits at the top of the reproductive hormone chain and sets the rhythm for everything below it.
Learn about KisspeptinHRT for women
Female Hormone Replacement Therapy (HRT)
Also known as: Hormone Replacement Therapy for Women, HRT for women
Provider-led hormone therapy, matched to your symptoms and labs, for the years around and after menopause.
- Focus
- Menopause hormone care
- Life stages
- Perimenopause & menopause
- Approach
- Lab-guided and individual
- Options
- Approved or compounded
Overview
What it is
Hormone replacement therapy, or HRT, replaces estrogen and progesterone as the ovaries make less of them. That shift happens during perimenopause, the years leading up to menopause, and after menopause itself.
Plans are built around your symptoms, labs, and health history. A licensed provider decides whether any hormone therapy is right for you.
Perimenopause is the stretch of years before periods stop for good. Cycles get irregular, sleep breaks up, moods shift, and hot flashes often start. Menopause itself is the point 12 months after a final period.
Views on hormone therapy have changed. A large study in the early 2000s led many women to stop, but later analysis showed that risk depends heavily on age, timing, and the type of hormone used.
Today the approach is individual. Type, form, and length of treatment depend on your age, your symptoms, your history, and your labs.
Benefits
What it supports
- Supports women dealing with hot flashes, night sweats, poor sleep, or mood changes
- Supports energy and daily comfort during and after the menopause transition
- Uses labs and symptoms to shape the plan rather than a one-size-fits-all recipe
- Includes ongoing monitoring and adjustments after the first evaluation
Mechanism
How it works
1
Estrogen and progesterone do far more than run the menstrual cycle. They affect body temperature, sleep, bone strength, mood, and the tissues of the vagina and bladder.
2
As the ovaries wind down, those hormone levels fall and swing. The symptoms most women notice, such as hot flashes and broken sleep, trace back to that change.
3
Hormone therapy adds back estrogen, and progesterone when you still have a uterus, since progesterone protects the uterine lining. It can come as a patch, gel, pill, spray, or vaginal product.
4
The form matters. Skin patches and gels, for example, carry a different clot risk than pills, which is one of the things a provider weighs for you.
Context
Who it's for
Women in their 40s and 50s dealing with broken sleep, brain fog, or mood swings
Women having hot flashes, night sweats, or trouble regulating temperature
Women trying to understand the difference between FDA-approved and compounded hormones
Women who want lab-guided care with follow-up rather than a one-time prescription
Landscape
In the landscape
How this therapy compares to related options—not a recommendation.
- Kisspeptin
Acts on the brain signal that drives hormone production, rather than replacing hormones. It has not been approved as a medicine.
Provider-directed
What providers review
- When your symptoms started and how much they affect daily life
- Estrogen, progesterone, FSH, and other related lab results
- Your personal and family history, including breast, uterine, clotting, and heart conditions
- Medicines you take now and any hormone treatment you have had before
- Bone health, thyroid function, and your overall metabolic picture
For therapies that require medical evaluation, every protocol is designed by a licensed provider.
Suitability for Female Hormone Replacement Therapy (HRT) is determined by a licensed provider after evaluation.
In this area
Related therapies
Other compounds that support overlapping wellness goals.
Questions
Female Hormone Replacement Therapy (HRT) FAQ
Good to know
Regulatory & considerations
Many hormone therapy products are FDA-approved for treating menopause symptoms. Custom-mixed compounded hormones, sometimes marketed as bioidentical, usually are not FDA-approved and are not held to the same testing standards. HRT is not right for everyone, and a licensed provider decides after an evaluation and lab work.
Therapies that require medical evaluation are sourced from FDA-regulated 503A compounding pharmacies.
For therapies that require medical evaluation, every protocol is designed by a licensed provider.
FDA-approved hormone products exist in many forms. Custom-mixed compounded hormones, often marketed as bioidentical, generally are not FDA-approved and are not held to the same testing standards.
Hormone therapy is not right for everyone. A history of breast cancer, blood clots, or certain heart conditions changes the picture, which is why the evaluation comes first.
Benefits and risks shift with age and with how long it has been since menopause. Starting earlier in the transition is a different decision than starting many years later.
This is ongoing care, not a single prescription. Expect regular check-ins and adjustments.
Shop Female Hormone Replacement Therapy (HRT)
See current pricing and availability for Female Hormone Replacement Therapy (HRT) in our shop. If a medical evaluation is needed, a licensed provider guides you through it.
Individual results vary. General information on this site is not a substitute for professional medical advice.