How is it different from the with-DAC version?

This one clears within hours, so the signal comes in short pulses. The with-DAC version attaches to a blood protein and stays active for days.

What is Modified GRF 1-29?

Another name for the same thing. It refers to the first 29 amino acids of the brain's growth hormone signal, with small changes so it lasts longer than the natural version.

Why is it often paired with ipamorelin?

They reach the pituitary gland through different receptors, so clinics name them together. That is a convention, not proof that combining them is better. Either can be used on its own.

Why is the naming so confusing?

CJC-1295 originally meant the long-acting version. The short-acting peptide picked up the same name over time, so without DAC and with DAC became the way to tell them apart.

How do I get started?

Head to our shop to see current availability and complete your order. Where a medical evaluation is required, a licensed provider reviews your health history—and may order labs—as part of the process.

Wellness & vitality

CJC-1295 (without DAC)

Also known as: Modified GRF 1-29

A short-acting copy of the brain signal that tells the pituitary gland to release growth hormone in short bursts.

Class: Growth hormone releaser
Also called: Modified GRF 1-29
Duration: Short-acting
FDA status: Not FDA-approved

Shop CJC-1295 (without DAC)

Overview

What it is

CJC-1295 without DAC, also called Modified GRF 1-29, is a lab-made copy of growth hormone-releasing hormone. The body clears it quickly, so its signal is short.

The natural brain signal for growth hormone breaks down within minutes. Researchers trimmed it to its first 29 amino acids and made small changes so it would survive longer, and that is Modified GRF 1-29.

The naming is genuinely confusing. CJC-1295 originally referred to the long-acting version. The short-acting one picked up the same name over time, so clinics add without DAC to tell them apart.

It is usually named alongside ipamorelin, because the two reach the pituitary gland through different receptors.

Benefits

What it supports

Supports lean muscle and post-training recovery through short growth hormone bursts
Supports body-composition goals tied to how the body uses fat
Supports sleep quality, energy, and daily vitality goals
Offers a shorter signal than the with-DAC version for people who prefer that pattern

Mechanism

How it works

The pituitary gland releases growth hormone in bursts, and the brain's releasing hormone is what triggers each burst.

This peptide copies that trigger. It binds the same receptors on the pituitary and prompts a burst of the gland's own growth hormone.

It clears within a few hours, so the signal comes and goes. That short pattern is closer to how the body does it naturally than a signal that stays on for days.

Growth hormone then raises IGF-1, and that pair is what the muscle, recovery, and body-composition claims are built on.

Context

Who it's for

Adults focused on lean muscle and recovery who prefer a short, pulse-like signal

People weighing the short-acting and long-acting CJC-1295 forms against each other

Adults looking at body composition through the growth hormone system

People trying to understand what the CJC-1295 / Ipamorelin name actually refers to

Landscape

In the landscape

How this compound compares to related options in the wellness landscape.

CJC-1295 (with DAC)
The long-acting version, which attaches to a blood protein and stays active for days rather than hours.
Ipamorelin
Reaches a different receptor in the same gland, which is why the two are often named together.

In this area

Related therapies

Other compounds that support overlapping wellness goals.

CJC-1295 (with DAC)

A longer-acting copy of the brain signal for growth hormone, changed so it sticks to a blood protein and stays active for days.

Learn about CJC-1295 (with DAC)

Ipamorelin

A lab-made peptide that nudges the pituitary gland to release growth hormone in its normal on-and-off pattern.

Learn about Ipamorelin

CJC-1295 / Ipamorelin

A named pairing of two growth hormone peptides that reach the pituitary gland through two different doors.

Learn about CJC-1295 / Ipamorelin

Tesamorelin

A prescription copy of the brain signal for growth hormone, approved to reduce excess belly fat in adults living with HIV.

Learn about Tesamorelin

Questions

CJC-1295 (without DAC) FAQ

Good to know

Regulatory & considerations

CJC-1295 without DAC is not FDA-approved. That means the FDA has not reviewed it for safety or effectiveness for the uses described here. Published human data is limited to small early studies.

Peptides in our shop are sourced from US-licensed manufacturers.

CJC-1295 without DAC is not FDA-approved, and its status under pharmacy compounding rules is still being decided.

Raising growth hormone can affect blood sugar and can cause fluid retention or joint aches.

The short-acting and long-acting forms are not interchangeable. How long the signal lasts is the whole difference.

Shop CJC-1295 (without DAC)

See current pricing and availability for CJC-1295 (without DAC) in our shop. If a medical evaluation is needed, a licensed provider guides you through it.

Shop CJC-1295 (without DAC)

Individual results vary. General information on this site is not a substitute for professional medical advice.